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Cushing Disease

Cushing's disease causes increased drinking, increased urination, increased appetite, panting, high blood pressure, hair loss - usually evenly distributed on both sides of the body, pendulous abdomen, thinning of the skin, calcified lumps in the skin, susceptibility to skin infections and diabetes, weakening of the heart
and skeletal muscles, nervous system disease and other symptoms. Most owners reach a point where the water consumption and urination become bothersome to them.

demodex

Severe inflammation of feet and legs from generalized
demodex. In generalized demodecosis there is a genetic defect that leads to an inability on the part of the dog's immune system to fight off this mite in most cases. Most dogs with immune system disorders that allow demodecosis to occur develop it at a younger age, usually less than one year of age. In dogs in which demodecosis occurs later, there is often something causing significant compromise of the immune system. Cushing's disease, liver disease, diabetes, high doses of prednisone or other cortisones, cancer and other strong suppressors of immune function can lead to adult onset demodecosis.